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Dr. Jennifer Brofft Bailey studies specific Bacteria/Archaea that are capable of nitrate assimilation, urea assimilation and ammonia oxidation in marine, freshwater and soil systems. Dr. Jennifer Zettler investigates the ecological effects of red imported fire ants on native invertebrates and plants. Together, both researchers are determining if fire ant mounds serve as “hot spots” for nitrification since they are enriched with oxygen and ammonia, conditions which should favor the growth of ammonia oxidizing Bacteria and Archaea.
Dr. Kathryn Craven - The hatch success of Leatherback sea turtle nests on the Georgia coast will be studied during the 2009 nesting season. Unhatched eggs collected from Leatherback nests will be examined to determine the duration of embryonic development. A second project is focused on in-water population monitoring and assessment of Diamondback Terrapins near Little Tybee Island.
Dr. Sara Gremillion - The fungi are an ecologically and economically important group of organisms. Dr. Gremillion is interested in highlighting the cellular components involved in proper fungal development using the model fungus Aspergillus nidulans. Mutations in two protein subunits of the conserved oligomeric Golgi (COG) complex have been linked to abnormal fungal growth. With the use of molecular genetic techniques, Dr. Gremillion is investigating the role of each of the subunits (COG1-8) in the function of the complex.
Dr. Brett Larson with Dr. Alex Collier - The effect of potential kairomones released by predators or alarm cues released by prey on larval tadpole development by measuring the length and weight of tadpoles exposed to predator fish or not and with or without being able to see the predator.
Dr. Scott Mateer - Biocatalysis is the use of microbes or their enzymes to generate chiral specific organic compounds that can be used as the building blocks for pharmaceuticals such as Prozac™. In short, biocatalysis is the use of little bugs to make big drugs. The ability of enzymes to generate these stereospecific molecules is not clearly understood. Dr. Scott Mateer, in collaboration with Dr. Brent Feske and Dr. Cliff Padgett, are trying to understand the molecular mechanisms that regulate an enzyme's stereoselectivity via mutagenesis of specific yeast reductases and subsequent analysis of the mutant reductase's ability to make chiral molecules. Their work is currently being funded by an NSF-RUI grant.
Dr. Traci Ness - Identification of genes involved in sea turtle immunity. One of the biggest challenges of research on sea turtles is that there are no commercially-available animals, cells, or turtle-specific reagents. Direct collection of samples from endangered species requires federal permits that are granted to a limited number of researchers. The Georgia Sea Turtle Center (Jekyll Island) has collected blood samples from loggerhead sea turtles. From the white blood cells, we are working to construct a cDNA library. From this library, we hope to identify, clone, and sequence genes involved in sea turtle immunity.
Identification and characterization of immune receptors that recognize fungal infections in the mouth. The oral cavity is continually exposed to a variety of microbes and patten recognition receptors (PRR,s) are responsible for discriminating between microbes and initiating an appropriate immune response. Most PRR research focused on immune cells; it is the epithelial cells that are present at the site of initial infection that must first recognize the invaders and alert and recruit immune cells to the site of infection. Dr. Ronald Garner (Mercer University School of Medicine) and I have begun a collaboration to investigate the recognition of the pathogenic yeast Candida albicans by PRR,s in oral epithelial cells. The primary goal of this project is to identify the PRR repertoire of these cells and to characterize the changes that occur following stimulation with Candiala. Ultimately, we will probe the PRR-Candida interactions that lead to the formation of signaling scaffolds on the surface of oral epithelial cells. These studies wlll provide us with a better understanding of oral immunity and may have applications in the treatment of oral diseases including those caused be microbes and oral cancers. We use a variety of molecular biology techniques: DNA/RNA purification, Polymerase Chain Reaction (PCR), gel electrophoresis, mammalian cell culture, western blot, enzyme-linked immunosorbent assay (ELISA), flow cytometry, and fluorescence microscopy.